Diclofenac Serratiopeptidase Paracetamol Tablets | Laadic-SP

Unveiling the Benefits and Risks of Diclofenac Serratiopeptidase Paracetamol Tablets

Introduction

Diclofenac Potassium, Serratiopeptidase, and Paracetamol tablets (Laadic-SP) are a three-drug fixed-dose combination. Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that helps to relieve pain and inflammation. Serratiopeptidase is a proteolytic enzyme that helps to repair damaged tissues and help in swelling and inflammation. Paracetamol is a well-known antipyretic drug used for fever and pain. 

This tablet (Laadic-SP) is used to treat several types of body symptoms like pain and inflammation associated with osteoarthritis, rheumatoid arthritis, joint disorder, muscle pain, back pain, toothache, headache, menstrual cramps, and fever.  

It is very important to understand this medication before use, it is a highly sensitive medicine for pregnant women. It can cause several types of injuries to the developing fetus so it should not be used without a doctor's advice. 

Composition of Laadic-SP

Each film-coated tablet contains:

• Diclofenac Potassium BP 50 mg
• Serratiopeptidase IP 15mg (As 30,000 units of Serratiopeptidase)
• Paracetamol IP 325 mg
• Excipients. q.s.
• Color: Red Oxide of Iron

Diclofenac Potassium: The strong pain reliever

Diclofenac Potassium is a Non-steroidal anti-inflammatory drug. It works by blocking the prostaglandins which is a chemical that is responsible for inflammation and pain in the body. As soon as the production of prostaglandins stops the message of inflammation and pain does not reach to brain. 

Diclofenac Potassium comes in different forms like tablets, capsules, extended-release tablets, topical gels, and injectables. 

Serratiopeptidase: The Anti-Inflammatory Enzyme

Serratiopeptidase is also known as serrapeptase. It is an enzyme that is derived from animals (silkworms). It helps to avoid protein breakdown in the body which reduces the swelling of the body. 

It is usually available in tablet forms in enteric-coated forms of tablets. The typical dose of serratiopeptidase remains 10mg Or 15 mg each tablet.

Paracetamol: Fever and Pain management

Paracetamol is a well known antipyretic and analgesic drug. It is also known as Acetaminophen in several countries. It is used to manage several pain situations like headache, migraine pain, backache, rheumatic and muscle pain, and largely fever. 

The mechanism of action of paracetamol is very complex, it blocks the chemical messengers in the brain that signals pain in the body. It also regulates the body temperature very well.

In the US, Canada, and Japan, it is known as Acetaminophen, however, in Europe, Australia, and India Paracetamol is its famous name. 

The Synergy of Diclofenac, Serratiopeptidase, and Paracetamol

In combination, when Diclofenac, Paracetamol, and Serratiopeptidase are blended in a tablet, they work together to provide more effective and fast pain relief. They reduce inflammation faster than they do it singularly. 

You can understand it as; Diclofenac and Paracetamol both work to reduce prostaglandin levels, but their mechanism is different to do it individually. Thus, they can control prostaglandin better when consumed together in tablet form. Additionally, Serratiopeptidase improves the absorption of Diclofenac and Paracetamol which makes them more effective. 

The combination of Diclofenac, Paracetamol, and Serratiopeptidase is also less likely to cause side effects than taking them in single-dose tablet form (Individually) because in combination their dose portion remains lower, in single molecule form Paracetamol remains 500 mg rather 325 mg in combination with Diclofenac and Serratiopeptidase.

Overall, the combination of Diclofenac, Paracetamol, and Paracetamol in a tablet makes it more effective than using them in different three tablets.

Conditions Treated with Diclofenac Serratiopeptidase Paracetamol Tablets

There are a lot of medical conditions that can be treated with Diclofenac, Serratiopeptidase, and Paracetamol tablets (Laadic-SP), some common conditions are:

• Arthritis and Joint Pain 
• Postoperative Pain Management 
• Dental Pain and Inflammation 
• Acute Injuries and Swelling
• Post-operative pain
• Musculoskeletal pain
• Menstrual cramps

Dosage and Administration Guidelines

Adult Dosage:

The accurate dose of Diclofenac, Paracetamol, and Serratiopeptidase tablets can be decided only by healthcare professionals. Do not consume this tablet without the advice of a doctor. Usually, it is recommended twice a day. 

Pediatric Dosage:

This tablet is not recommended for children. Always consult your doctor if you are willing to use it in children. 

Duration of Treatment:

The duration of the course of this tablet depends on the symptoms being treated with it. Additionally, your doctor can decide the duration of the Laadic-SP tablet as per your health conditions. 

Detailed Description of Laadic-SP Tablet

Laadic-SP Diclofenac Paracetamol Serratiopeptidase Tablets are used to treat pain, inflammation, headache, and fever. This is also used in tooth pain, muscle pain, and back pain.

The use of Serratiopeptidase increases the efficacy of diclofenac Potassium and paracetamol in certain types of pain.

Laadic-SP Diclofenac Paracetamol and Serratiopeptidase tablets are used for pain relief. It also relieves pain in conditions like headaches, mild migraines, musculoskeletal pain, or painful menses, It is very helpful in the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis in adults.

This combination is used very much in muscle fracture and bone pain. This is known as safer than Ibuprofen & Paracetamol Tablets.

The use of this drug should not be prolonged who have kidney and liver disease.

Safety and Precautions

Common Side Effects of Laadic-SP Tablet:

This is a potent medication and sedative in nature so it has some side effects that are not severe. common side effects are Nausea, Vomiting, Stomach pain, Indigestion, Heartburn, Loss of appetite, and Diarrhea in some cases.

Allergic Reactions:

Diclofenac, Paracetamol, and Serratiopeptidase tablets (Laadic-SP) are generally well-tolerated, but they can cause allergic reactions in some people. The most common allergic reactions to these drugs may include:

• Skin rash
• Hives
• Itching
• Swelling of the face, lips, tongue, or throat
• Difficulty breathing

Contraindications:

Diclofenac, Paracetamol, and Serratiopeptidase tablets (Laadic-SP) may be contraindicated in the following cases:

• Allergy to any of the drugs or their excipients
• Active peptic ulcer or inflammatory bowel disease
• Severe heart failure
• Severe liver or kidney disease
• History of asthma or other allergic reactions to NSAIDs
• Pregnancy and breastfeeding

The best way to avoid any drug contradiction is to follow the instructions of the doctor, and not take any medicine without his permission along with this combination.

Long-Term Use and Monitoring

Risks of Prolonged Use:

It has been found that long-term use of Diclofenac, Paracetamol, and Serratiopeptidase can harm some important organs in the body such as the liver, and kidneys. 

Regular Check-ups:

You avoid adverse effects on several different organs in the body by getting regular health check-ups. If you feel any abnormality in the report discontinue the use of this tablet.

Alternatives and Consultation with Healthcare Providers:

If you are feeling any type of allergy or threatening signal from your analysis report. You can change this with other analgesics or pain reliever formulations such as Paracetamol 650 mg or Ibuprofen with Paracetamol and Serratiopeptidase.

Short description

Brand Name: LAADIC SP

Dosage Form: Tablets

Composition: Paracetamol IP 325mg.+Diclofenac Potassium IP 50mg.+Serratiopeptidase 15mg.

Packing: 10*10 Blister

MRP: Rs. 95.00 per 10  Tablets

Also Available;

LAADIC-MR :Diclofenac+Paracetamol+Chlorzoxazone Tablets

FEFON-XT-SYRUP: Ferrous Ascorbate eq. to elemental Iron 30mg AND Folic Acid 550 mcg

FASTER GEL: (Linseed Oil 3%, Diclofenac Sodium 1%, Methyl Salicylate 10 % and Menthol 5% Gel.)

Foncef- SB-1.5g  (Ceftriaxone 1gm+Sulbactam500mg)

Foncef-1gm (Ceftriaxone 1gm)

LOBULAR-GM: (Clobetasol Propionate 0.5%, Neomycin Sulphate 0.5 %, Miconazole Nitrate  2% Cream.

Faster gel: Diclofenac, Linseed Oil, Salicylic acid, and Menthol gel

Tinto-MH Cream-: (Mometasone, Tretinoin, and Hydroquinone Cream)

COZICOF-LS : Ambroxol Hcl 15 mg+Levasalbutamol 1mg.+Guaiphenesin 50mg/5 ml

Fonvital Plus: Ginseng with Multivitamins, Minerals & Antioxidants capsules

Mecome-Alpha: Methylcobalamin alpha-lipoic acid pyridoxine Hydrochloride,  folic acid, and Thiamine Mononitrate

FASTER PAIN OIL: An herbal joint pain oil

Neurozil Forte Injection.: Methylcobalamin Injection 2500 mcg Dispo pack 

References:

1. NSAIDs-[NHS(.uk)]
2. Proteolytic Enzymes (Proteases) - Uses, Side Effects, and More-[WebMD(.com)]
3. The anti-inflammatory action of a protease, TSP, produced by Serratia[National Library of Medicine]
4. Paracetamol:[Healthdirect(gov.au)]
5. Diclofenac-Serratiopeptidase Combination Induced Stevens-Johnson Syndrome - A Rare Case Report with Review of Literature-by Saibal Moitra,Sukanta Sen, Indranil Banerjee, Prasanta Das, and Santanu K Tripathi [(PubMed Central(PMC)]

Disclaimer:

Disclaimer: All the information and articles available on this site are for educational purposes only. The information given here should not be used for the diagnosis or treatment of any health problem or disease without expert advice. The advice of a qualified medical practitioner should always be sought for medical examination and treatment.

Reviewed by;

Dr. Yogesh Chaudhary (B. Pharma)

Senior Pharmacist at S.N. Medical College, Agra-(UP)