Exploring the Benefits and Uses of Chlorzoxazone-Paracetamol-Diclofenac Potassium Tablets
Introduction:
Chlorzoxazone-Paracetamol-Diclofenac Potassium (Laadic-MR) Tablets is a pain reliever muscle relaxant tablet. It is a well-known pain management medicine that is used to relieve muscle pain, joint pain, back pain, and lower back pain due to kidney diseases.
Diclofenac Potassium+Paracetamol+Chlorzoxazone is a combination of three molecules that are used in medication-based pain management.
Composition of Chlorzoxazone-Paracetamol-Diclofenac Potassium Tablets
The composition of this fixed dose combination is given below:
Each film-coated tablet contains:
- Diclofenac Tartrazine IP 50 mg,
- Paracetamol IP 325 mg,
- Chlorzoxazone USP 250 mg
- Excipients........q.s.
- Color: Tartrazine
Diclofenac Potassium:
Diclofenac Potassium is a nonsteroidal anti-inflammatory drug (NSAID). It is used to treat pain, and inflammation in different conditions. It is a non-selective NSAID. It blocks the production of both COX1 and COX2. These two enzymes are responsible for inflammation and pain in the body.
Diclofenac Potassium usually comes in oral dose forms tablets and capsules. The usual dose of Diclofenac Potassium is 50 mg thrice a day. However, the right dose for an individual should be decided by the doctor.
Paracetamol:
Paracetamol is a potent antipyretic and analgesic drug. It is used to relieve pain and fever. It is also known as Acetaminophen. It is also covered in the nonsteroidal anti-inflammatory drug category. However, the mechanism of action of Paracetamol is different from Diclofenac but both block the production of prostaglandins. Prostaglandins are a hormone chemical that is responsible for inflammation and pain.Paracetamol is available in all dosage forms such as tablets, capsules, Liquid Orals, Oral drops, and Injections. The daily dose of paracetamol depends on the conditions of the patient, age, weight, and type of symptoms also impact the dose. Let your doctor suggest the right dose of paracetamol, and follow his/her instructions.
Chlorzoxazone:
Chlorzoxazone is a muscle relaxant drug that is usually available in tablet form. It is used for acute muscle pain and bone pain. It is a Schedule-H Drug that is a prescription medicine. It is used only after the prescription of a Registered Medical Practitioner. It is a skeletal muscle relaxant. It works on the central nervous system (CNS) to relax muscles.
Chlorzoxazone was first time synthesized in 1956 by J.R. Geigy AG, a Swiss pharmaceutical company. It was approved for medical use in the United States in 1958.
Synergetic effects of Paracetamol, Diclofenac, and Chlorzoxazone:
The combination of Chlorzoxazone, Paracetamol, and Diclofenac Potassium is used to relieve muscle and bone pain. In this tablet, Chlorzoxazone's role is to relax the muscle by working on the centers in the brain and spinal cord, it relieves muscle stiffness, and spasm that improves muscle movement.
Diclofenac Potassium is a nonsteroidal anti-inflammatory drug (NSAID), it works by blocking the production of a chemical messenger known as cyclo-oxygenase (COX) that causes pain and inflammation at the spot of injury.
Paracetamol is a mild analgesic and strong antipyretic, it enhances the capabilities of diclofenac in pain relief. This combination is a well-proven formula for pain relief. It is further advised, to ask your doctor before taking this medication.
Medical Applications of Chlorzoxazone, Paracetamol and Diclofenac Tablet:
Paracetamol, Chlorzoxazone, and Diclofenac (Laadic-MR) Tablets are muscle relaxant that blocks pain sensations between the nerves and the brain. Some significant medical uses of this combinations are as follows;
- Pain Relief
- Muskotel pain
- Joint pain
- Arthritis Pain
- Back pain
- Spinal cord pain
- Muscle pain
- Fever
- Post-surgery pain
Dosage and Administration:
A. Recommended Dosage:
This combination usually comes with Paracetamol 325 mg, Diclofenac 50 mg, and Chlorzoxazone 250 mg in each tablet, doctor recommends one tablet two times a day, in emergency high pain they allow one tablet three times a day.
Always follow your physician's recommendations for dosage and period of course of this medication.
B. Administration Guidelines:
Swallow the tablet with the help of water or juice. Do not chew or crush the tablet because it is very bitter in taste, and it can cause vomiting.
C. Considerations for Special Populations:
It is a strong pain relief formula. It is always suggested that follow the instructions of a physician before taking this combination medicine. This medication is not recommended for children, pregnant women, and breastfeeding mothers. Ask your doctor for further information.
Safety and Side Effects:
A. Common Side Effects of Paracetamol, Diclofenac and Chlorzoxazone:
The most common side effects of Paracetamol, Diclofenac, and Chlorzoxazone tablets include:
- Nausea and vomiting
- Upset stomach
- Heartburn
- Diarrhea
- Dizziness
- Drowsiness
Some serious side effects are;
- Liver damage
- Kidney damage
- Skin rash
- Allergic reaction
B. Precautions and Warnings
Chlorzoxazone, Paracetamol, and Diclofenac Potassium tablets are stronger formulas, a three-drug combination. It is not a common medicine that can taken freely from OTC and consumed, it is a very sensitive tablet that can cause many side effects on the skin, allergic reactions, and damage to the developing fetus in pregnant women. So it is important to consult your doctor before taking it.
Some precautions that should be kept in mind while using this combination;
- Consult your doctor before starting the course of Chlorzoxazone, Paracetamol, and Diclofenac Potassium tablets.
- Children and pregnant women should not take it from OTC.
- Do not exceed the recommended dose of the Laadic-MR tablet.
- Be aware of drug interaction with other medicines if you are taking this combination.
- Liver patients always consult with their doctor while taking this medicine.
- Kidney patients do not take the maximum recommended dose of the tablet.
C. Drug Interactions
Laadic-MR tablet has three molecules Chlorzoxazone, Paracetamol, and Diclofenac Potassium, each of them can interact with many other drugs, so the possible interacting groups are listed below:
- Alcohol
- Anticoagulants (blood thinners)
- Anticonvulsants (seizure medications):
- Barbiturates
- Aspirin (acetylsalicylic acid):
- Corticosteroids
- Lithium
- Anesthetics
- Antidepressants
- Antihistamines
SHORT DESCRIPTION
- Brand Name: LAADIC-MR
- Dosage Form: Tablets
- Composition: Diclofenac Potassium 50 mg, Paracetamol 325 mg, and Chlorzoxazone USP 250 mg Tablets
- Packing: 10*10 Blister
- MRP: Rs. 85.00 PER 10 TABLETS
- Shelf Life: 2 years
Substitutes of Laadic-MR tablet in India:
Also available;
Laadic-P (Diclofenac Potassium& Paracetamol tablets)
Laricold Tablet: Levocetirizine, Phenylephrine, and Paracetamol tablet.
Rebfon-DSR (Rabeprazole 20mg +Domperidone 30mg)
Fonvital Plus: Ginseng with Multivitamins, Minerals & Antioxidants capsules
Mecome-Alpha: Methylcobalamin alpha-lipoic acid pyridoxine Hydrochloride, folic acid, and Thiamine Mononitrate
DOWN-A SUSPENSION: Aceclofenac and Paracetamol suspension
KUFTIPS SYRUP: An Ayurvedic cough syrup
Itco-200: Itraconazole capsules 200 mg
References:
- Cyclooxygenase-1Burkhard Hinz, Andreas Pahl, in xPharm: The Comprehensive Pharmacology Reference, 2007:[Sciencedirect(.com)]
- COX-2 Inhibitors-[Claveland Clinic]
- Emanuela Ricciotti, Ph.D. and Garret A. FitzGerald, MD.-Prostaglandins and Inflammation; PMC 2012 May 1 [PMC PubMed Central]
- Chlorzoxazone-[Wikipedia(.Org)]
- Patel, H.D., Uppin, R.B., Naidu, A.R. et al. Efficacy and Safety of Combination of NSAIDs and Muscle Relaxants in the Management of Acute Low Back Pain. Pain Ther 8, 121–132 (2019). https://doi.org/10.1007/s40122-019-0112-6-[Springer link]
Disclaimer:
Disclaimer: All the information and articles available on this site are for educational purposes only. The information given here should not be used for the diagnosis or treatment of any health problem or disease without expert advice. The advice of a qualified medical practitioner should always be sought for medical examination and treatment.
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