Levosalbutamol, Ambroxol Hydrochloride and Guaiphenesin syrup | Cozicof-LS

Levosalbutamol + Ambroxol + Guaifenesin Syrup Uses, and Side effects 

Introduction:

Levosalbutamol, Ambroxol Hydrochloride, and Guaiphenesin syrup is a productive and asthmatic cough syrup. It is used to treat mucus cough. It is also recommended for asthmatic patients. It is an oral medicine that is taken by mouth a maximum of three times a day. This combination can cause nausea, vomiting, and diarrhea as side effects. 

It is a unique combination of three different category ingredients. Levosalbutamol is a bronchodilator in class. It relaxes the muscles in the airways which makes breathing easy. Another ingredient Ambroxol is a mucolytic drug that helps to break down mucus and make it easier to cough out. The third ingredient present in this syrup is Guaiphenesin which is expectorant in nature. It loosens mucus and helps cough easier. 

What is Levosalbutamol, Ambroxol Hydrochloride, and Guaiphenesin Syrup?

Cozicof-LS syrup is a Levosalbutamol sulfate, Ambroxol hydrochloride, and Guaiphenesin syrup which is a potent cough syrup in asthmatic patients and old age patients. It contains Levosalbutamol 1mg which is very effective in patients who feel breathing halts during cough, Ambroxol 30 mg present in the syrup dilutes the mucus or phlegm which blocks the airways of breathing. Guaiphenesin is an expectorant that allows breathing smoothly and keeps the airways smooth.

Indications of this combination are productive cough, cough with phlegm, allergy cough, asthmatic cough, and cough due to dust.  

LEVOSALBUTAMOL SYRUP:

Levosalbutamol/Levalbuterol, Ambroxol Hydrochloride & Guaiphenesin Syrup is used to treat asthma disease and cough related to asthma. On many occasions single bronchodilator does not work in cough symptoms then such a combination works better in cough. Patients who do smoking regularly feel a problem breathing while coughing. Levosalbutamol syrup is very effective in such conditions.

LEVOSALBUTAMOL AMBROXOL HYDROCHLORIDE GUAIPHENESIN SYRUP USES

Cozicof-LS Syrup (Levosalbutamol, Ambroxol & Guaiphenesin Syrup) is used to treat cough and conditions like chest congestion, sinusitis, bronchitis, asthma, respiratory problems, and the common cold. It is also used to relieve patients suffering from lung inflammation, thickened mucus cough, etc.

This combination also relieves cough with mucus, ambroxol loosens mucus (phlegm) and relieves cough symptoms. Ambroxol Hydrochloride promotes mucus clearance and starts expectoration which brings down the productive cough.

Levosalbutamol is a bronchodilator that is best in chronic obstructive pulmonary disease. It relaxes the muscles in bronchial tubes which tends to reverse the attack of asthma breathing difficulty. Ambroxol also helps to allow patients to breathe freely and deeply.

Guaiphenesin present in this combination works as throw cough out phlegm from the airways which allows breathing to enter freely. However, this medication is not recommended for children below 6 years of age. Guaiphenesin increases the efficiency of the cough reflex and facilitates the removal of secretions.

Levosalbutamol + Ambroxol + Guaifenesin Syrup side effects:

This combination of Levosalbutamol, Ambroxol & Guaiphenesin has been counted as a safe medication but it may have some side effects in some health-compromised patients, like elevated heart rate, muscle cramps, and gastric upset. Overdose may turn to seizure and chest pain, and in rare cases, it may lead to paradoxical bronchospasm.

AMBROXOL + LEVOSALBUTAMOL + GUAIFENESIN SYRUP NAMES

There are some popular brand names of Levosalbutamol, Ambroxol, and Guaiphenesin syrups are below:-

• Ambrodil-LX
• COZICOF-LS
• LEVOLIN PLUS
• Bro-Zedex-LX
• Asthalin-AX
• Chericof-LS
• Macbery-Junior
• Brozeet-LS
• Kufril-LS
• Ascoril-LS

Dosage and Usage Guidelines:

The recommended dose for adults: The recommended dose of Levosalbutamol, Ambroxol, and Guaiphenesin is 5ml thrice a day. It can vary for particular patients with specific symptoms. For the right dose, you should consult your doctor. 

Pediatric Dosage and Age-Specific Instructions: This combination is not recommended for children below 6 years of age. Elder age patients should be advised by a doctor before taking this medication.

Timing and Duration of Treatment: Usually, this medication is taken three times a day after the meal. The treatment with three medicine combination syrup can lead up to 15 days if the doctor feels it necessary. 

Administration Method: The administration of syrup is recommended by mouth. 

Safety Precautions and Potential Side Effects:

The Cozicof-LS syrup ( Levosalbutamol, Ambroxol, and Guaiphenesin syrup) should not be taken without a consultation with a doctor. It is a high-efficiency medicine thus it can have some side effects if not used as per medical guidance. 

Potential Side effects:

Some common side effects of Levosalbutamol, Ambroxol, and Guaiphenesin syrups are as below:

• Nausea
• Vomiting
• Drowsiness
• Headache
• Dizziness
• Skin rash
• Tremor
• Stomach upset
• Diarrhea

Drug Interactions with Cozicof-LS Syrup:

The Cozicof-LS or Levosalbutamol, Ambroxol, and Guaiphenesin syrup have three different ingredients that singularly have drug interactions. It is very important to keep in mind drug interactions and contradictions of all three molecules present in the blended syrup. You must consult your doctor if you are taking any other medicine along with this syrup.

Some common drugs that may interact with this combination include:

• Fluid retention drugs (Furosemide)
• Heart-related drugs (Digoxin)
• Fluticasone
• Budesonide
• Salmeterol
• Vilanterol
• Erythromycin
• Doxycycline
• Cefuroxime

What is Brozeet LS used for?

Brozeet-LS Syrup is a combination of levosalbutamol, Ambroxol, and Guifenesin medicines used to treat coughs that produce mucus. Brozeet LS works by thinning the mucus in the nose, windpipe, and lungs, making it easier to throw cough out. It provides relief from a runny nose, sneezing, itching, and watery eyes.

In fact, Brozeet-LS Syrup is not a permanent cure for the underlying cause of the cough with mucus, but it can help to relieve the symptoms and make you feel more comfortable for a short time.

How does Brozeet work?

Brozeet is a combination medicine that contains three active ingredients:

• Ambroxol is a mucolytic, which means it thins mucus deposited in the lungs and airways. This makes it easier to cough up mucus and clear your airways.
• Levosalbutamol is a bronchodilator, which means it relaxes the muscles in the airways. This makes it easier for air to flow in and out of your lungs.
• Guaifenesin is an expectorant, which means it helps to loosen mucus in the lungs and airways. This makes it easier to cough up mucus and clear your airways. 

Brozeet works by combining the effects of these three active ingredients to thin, loosen, and remove mucus from the lungs and airways. This makes it easier to breathe and can help to relieve coughs associated with mucus production.

SHORT DESCRIPTION

Brand Name: Cozicof-LS

Dosage Form: Liquid Oral/ Syrup

Composition: Levosalbutamol 1 mg, Ambroxol Hydrochloride 30 mg & Guaiphenesin 50mg./ 5 ml

Packing: 100 ml with box

MRP: Rs. 100.00

Also Available;

FTOX-AM: (Ambroxol Hcl 15 mg+Terbutaline Sulphate 1.25mg.+Guaiphenesin 50mg.+Menthol 2.5 mg./5 ml)

FTOX-DX: (Dextromethorphan Hbr 10mg.+CPM 2mg.+Phenylephrine HCL 5mg. sorbitol (70%)

Reference:

• Wikipedia, the free encyclopedia
• Ambroxol: From Wikipedia, the free encyclopedia
• Drugs & Medications-Guaifenesin-WebMD
• Ambroxol Hydrochloride [Drugs.com]
• Levosalbutamol [ScienceDirect]
• Guaifenesin [MedlinePlus(.gov)]
• Levosalbutamol-Drug Interactions [Go-drugbank-online]

Disclaimer:

Disclaimer: All the information and articles available on this site are for educational purposes only. The information given here should not be used for the diagnosis or treatment of any health problem or disease without expert advice. The advice of a qualified medical practitioner should always be sought for medical examination and treatment.

Reviewed by;

Dr. Yogesh Chaudhary (B. Pharma)

Senior Pharmacist at S.N. Medical College, Agra-(UP)