Understanding Sildenafil Citrate Tablets 100mg
Introduction:
Sildenafil Citrate is a medicine used to treat erectile dysfunction in men. It is also used in pulmonary arterial hypertension (PAH) in both men and women. Sildenafil works by relaxing the muscles of blood vessels and increasing the blood flow to the penis.
It is available in the form of tablets. It is recommended to take with or without food 30 minutes before sexual activity. The dosage of Sildenafil citrate may vary as per the conditions of the patient and age.
What is Sildenafil Citrate?
Sildenafil Citrate is a drug that was initially approved by the FDA in 1998 under the brand name Viagra. The mechanism of action of Sildenafil Citrate is to relax the blood vessel in the penis, it allows more blood into the specific area. This helps men to get an easy erection.
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Mechanism of Action: How Sildenafil Citrate Works:
Sildenafil Citrate is a PDE5 (Phosphodiesterase-5) inhibitor that blocks the action of PDE5. Phosphodiesterase-5 (PDE5) is an enzyme that is used to break down Cyclic Guanosine Monophosphate. This molecule helps to relax the muscle cells in the blood vessels in the penis. Sildenafil helps to keep blood vessels relaxed by blocking the breakdown process of Cyclic Guanosine Monophosphate (cGMP). This complete process helps men to get and maintain an erection.
Medical Uses of Sildenafil Citrate Tablets 100 mg
L-Force Sildenafil tablet 100mg is used to treat sexual function problems (impotence or erectile dysfunction-ED) in men. Sildenafil works by increasing blood flow to the penis to help a man get capabilities and keep an erection action. This is believed to be the best drug to provide a high level of orgasm to males who are suffering from erectile dysfunction
L-Force-100mg Sildenafil tablet 100mg is a drug used to treat erectile dysfunction and pulmonary arterial hypertension in men. It is also effective for treating sexual dysfunction in women. It is taken by mouth. This is 4 tablets packed in a blister strip with a mono box and 10 mono boxes in the outer box.
Pulmonary Arterial Hypertension (PAH) and Sildenafil Citrate:
Pulmonary Arterial Hypertension (PAH) is a rare type of disease that is responsible for high blood pressure in the lungs. This can create difficulty for the heart to pump blood into the lungs. It can lead to breathing shortness. Sildenafil Citrate is a medication that treats PAH, it relaxes the blood vessels in the lungs. It makes it easy for the heart to pump blood into the lungs.Sildenafil citrate is a medication that is used to treat PAH. It works by relaxing the blood vessels in the lungs, which makes it easier for the heart to pump blood and improves the symptoms of PAH. It is usually taken by mouth and the effects start within 30 minutes after taking it.
Role in Sexual dysfunction
The main function of sildenafil citrate tablets is the treatment of erectile dysfunction (an inability to sustain a satisfactory erection to complete sexual intercourse). Sildenafil Citrate is now one of the frontline treatments for erectile dysfunction, and people suffering from diabetes also have a big improvement in erectile dysfunction. This medication has tentative evidence that suggests that sildenafil can help men who experience antidepressant-induced erectile dysfunction. Rather than this, sildenafil improves some markers of disease in people with pulmonary arterial hypertension disease.
Raynaud's Phenomenon Treatment with Sildenafil Citrate
Sildenafil citrate tablet is used to alleviate vasospasm and treat severe ischemia and ulcers in the fingers and toes of people with secondary Raynaud’s phenomenon. According to a clinical trial titled: "Sildenafil in the treatment of Raynaud's phenomenon resistant to vasodilatory therapy" initially published in 2005, "Sildenafil is an effective and well-tolerated treatment in patients with Raynaud's phenomenon."
Safety Precautions and Considerations
COMMON SIDE EFFECTS:
Sildenafil Citrate Tablets 100mg have the most common side effects that may include headache, flushing, indigestion, nasal congestion, impaired vision, including photophobia, and some cases blurred vision.
Drug Interactions:
People who are taking protease inhibitors for the treatment of HIV infection should take care extra while taking Sildenafil Tablets because Protease inhibitors inhibit the metabolism of sildenafil which can multiply the plasma levels of sildenafil which can increase the incidence and severity of Sildenafil’s side effects. People using protease inhibitors should not consume sildenafil more than one 25 mg dose, every 48 hours.
Other than Protease inhibitors, erythromycin, and cimetidine can interfere with the metabolism of sildenafil citrate, erythromycin and cimetidine can lead to prolonged plasma half-life levels.
Who Should Avoid Sildenafil Citrate Tablets?:
Sildenafil Citrate is a prescription medicine. It is a very strong medicine in terms of adverse effects on the body of consumers. Such medicines should not be used without the consultation of a doctor. The following people should avoid sildenafil citrate tablets:
- People who are allergic to sildenafil or any of its ingredients or excipients.
- People who are taking medicines called nitrates for chest pain (angina).
- People who have a serious heart or liver problem.
- People who have recently had a stroke, heart attack, or heart problem.
- People who have low blood pressure (hypotension).
- People who have a rare inherited eye disease, such as retinitis pigmentosa.
- People who are taking riociguat, a medication used to treat pulmonary arterial hypertension.
- People who are taking alpha-blockers, a type of medication used to treat high blood pressure and prostate problems.
- People who are taking other medications that interact with sildenafil, such as some antibiotics, antifungals, and HIV medications.
Understanding Dosage and Administration
Recommended Dosage of Sildenafil Citrate Tablets 100 mg: The recommended dosage of sildenafil citrate tablets is 50 mg which is taken 30 minutes before sexual activity. The dose may be increased to 100 mg or decreased to 25 mg based on effectiveness and tolerability. The maximum recommended dose is 100 mg. The maximum recommended dosing frequency is once per day. It is highly recommended that you advise the doctor to avoid any side effects of the drug.Factors Affecting Dosage:- Age, Health, and Medical History: The dose of Sildenafil Citrate may be decreased or increased on the basis of the age of the patient, the health status of an individual, and the medical history of the individual can also impact the dose.
About L-Force-100:
BRAND NAME: L-FORCE-100
COMPOSITION: Each film-coated tablet contains
Sildenafil Citrate IP Eq. to Sildenafil 100mg
PACKING: 1X4 TABLET BLISTER
MRP: Rs. 128.00
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References:
- Sildenafil citrate 100 mg starting dose in men with erectile dysfunction in an international, double-blind, placebo-controlled study: effect on the sexual experience and reducing feelings of anxiety about the next intercourse attempt [National Library of Medicine]
- Pulmonary Arterial Hypertension-Reviewed by Melinda Ratini, MS, DO on August 10, 2023 [WebMD]
- VIAGRA® (sildenafil citrate) tablets, for oral use Initial U.S. Approval: 1998 [Food and Drug Administration (.gov)]
- Cyclic Guanosine Monophosphate-S.H. Francis, J.D. Corbin, in Encyclopedia of Biological Chemistry (Second Edition), 2013 [Sciencedirect (.com)]
- Sildenafil in the treatment of Raynaud's phenomenon resistant to vasodilatory Therapy: Roland Fries, Kaveh Shariat, Hubertus von Wilmowsky, Michael Böhm [PubMed]
- Sildenafil Dosage- [Drug (.com)]
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