Cyproheptadine Hydrochloride and Tricholine Citrate Syrup | Gcyp Plus

Darshan Singh
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Cyproheptadine Hydrochloride 

Cyproheptadine Hydrochloride and Tricholine Citrate syrup is a combination of two medicines used to treat appetite loss. It is also prescribed for people who are suffering from weight loss symptoms. Anorexia Nervosa is also can treated with this medication. 
Cyproheptadine Hydrochloride is an antihistamine drug that blocks the effects of serotonin. Serotonin is responsible for regulating appetite, sleep, and other functions. 

Tricholine Citrate is a bile acid binding agent. It is produced by the liver and works to digest the fat. 

It is essential to know about the medication before taking this medicine. Cyproheptadine Hydrochloride is a Schedule G Drug prescribed medicine in the Drug and Cosmetics Act of 1940. This medication should used under the guidance of a health professional. 
Cyproheptadine Hydrochloride and Tricholine Citrate Syrup | Gcyp Plus


Understanding Cyproheptadine Hydrochloride

    What is Cyproheptadine Hydrochloride?

    Cyproheptadine is a first-generation antihistamine. It was patented in 1959 in the United States. In 1961, it was introduced for medical use in the market. It has anticholinergic and anesthetic properties also. However, Periactin tablet 4 mg was approved in 1999 by the FDA. 
It blocks the effects of Serotonin (A chemical messenger) that is involved in controlling appetite and sleep. It increases the appetite without harming body functions. 

Indications for Cyproheptadine Hydrochloride Use:

Cyproheptadine is indicated for several symptoms, it is recommended firmly always consult your doctor before use. Some common indications for which cyproheptadine is prescribed: 
  • Perennial and seasonal allergic rhinitis
  • Vasomotor rhinitis
  • Allergic conjunctivitis due to inhalant allergens and foods
  • Mild, uncomplicated allergic skin manifestations of urticaria and angioedema
  • Amelioration of allergic reactions to blood or plasma
  • Cold urticaria
  • Dermatographism

Tricholine Citrate: Exploring the Basics:

Tricholine Citrate is a dietary supplement. It is made from choline and citrilline. It is sold as a weight loss supplement, however, there is not sufficient scientific evidence in this support.

Tricholine Citrate is a supplement that is used to treat high cholesterol. It removes the excess bile acids from the body. It can combined with Cyproheptadine and other ingredients to stimulate appetite. It is also used to enhance memory and cognitive function. 

It is an essential nutrient for brain development and its function. It helps to produce acetylcholine which is a neurotransmitter for memory. 
Tricholine Citrate works by increasing the production of acetylcholine and nitric oxide in the body. This helps to improve memory, cognitive function, and weight loss. 

It is considered safe for the general population if taken in a prescribed dose. Some side effects like nausea, vomiting, and diarrhea are possible. 


GCYP PLUS is Cyproheptadine and Tricholine citrate syrup which is an appetite stimulant. Gcyp plus reduces the effect of a chemical messenger named serotonin present in the hypothalamus, which is a part of the brain that has the function of regulating the appetite. Tricholine citrate present in Gcyp Plus is a bile acid-binding agent that removes bile acids from the body.

Cyproheptadine and Tricholine citrate syrup Uses:


GCYP PLUS cyproheptadine is used to increase appetite deficiency or hunger and is also used for weight gain.

The role of Tricholine Citrate in GCYP Plus is very important. Tricholine is a bile acid-binding agent that removes bile acids from the body, then the liver produces more bile acid using cholesterol. Therefore, the levels of cholesterol in the body come down.

Possible side effects of Cyproheptadine:

The common side effects of Cyproheptadine and tricholine citrate syrup are drowsiness, dizziness, blurred vision, constipation, and dry mouth/nose/throat, which may occur in a few cases. 

Medical Conditions Treated with Gcyp Plus:

Cyproheptadine and Tricholine Citrate syrup is used for the treatment of various medical conditions as follows;

Allergies and Their Management:

Cyproheptadine is an antihistamine that blocks the effects of histamine. It can be used to treat a variety of allergic symptoms, including sneezing, runny nose, itchy eyes, and hives.

Appetite Stimulation and Weight Gain:

Cyproheptadine and Tricholine Citrate syrups are used to stimulate appetite. This combination increases the appetite by blocking the messenger Serotonin hormone. 

Liver Disorders and Tricholine Citrate:

The combination of Cyproheptadine and Tricholine Citrate is helpful in boosting appetite. However, there are some concerns about Tricholine Citrate that it may increase existing liver disorders. It can increase the liver enzymes in people with non-alcoholic fatty liver disease. It may lead to cirrhosis and liver cancer if not controlled. 

Short Description

Brand Name: GCYP PLUS

Dosage Form: Syrup

Composition:  Cyproheptadine HCl 2mg+Tricholine Citrate (65%) 275mg/5ml

Packing: 200 ml

MRP: Rs.130.00

Also Available :

COZICOF-LS : Ambroxol Hcl 15 mg+Levasalbutamol 1mg.+Guaiphenesin 50mg/5 ml

Fonvital Plus: Ginseng with Multivitamins, Minerals & Antioxidants capsules

Mecome-Alpha: Methylcobalamin alpha-lipoic acid pyridoxine Hydrochloride,  folic acid, and Thiamine Mononitrate
DOWN-A SUSPENSION: Aceclofenac and Paracetamol suspension

KUFTIPS SYRUP: An Ayurvedic cough syrup

Itco-200: Itraconazole capsules 200 mg

Laadic-MR Tablet: Diclofenac Potassium, Chlorzoxazone and Paracetamol Tablet.

References: 

  1. Cyproheptadine Hydrochloride Syrup- [National Institute of Health (.gov)]
  2. Periactin-4mg tablet- Approval Letter [Food and Drug Administration (.gov)]
  3. Cyproheptadine Prescribing Information [Drugs(.com)]

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