Cefixime and Ofloxacin tablet | Ceffon-Ox Tablet

Cefixime + Ofloxacin: View Uses, Side Effects and Medicines

Introduction: 

Ceffon-OX Tablet is  Cefixime and Ofloxacin Tablets which is used in used to treat Typhoid, Infections. bronchitis, pneumonia, urinary tract infections (UTIs), and gonorrhea. In this blend of medicine, Cefixime is a third-generation cephalosporin, while Ofloxacin is a fluoroquinolone antibiotic. CDSCO approved this combination(Cefixime+Ofloxacin) as a new drug on 26.04.2010 for the treatment of patients with typhoid fever and urinary tract infection in adults.

It is a very effective synergy of two medicines that are effective against several types of bacteria where many antibiotics do not found effective.

Understanding Cefixime:

Cefixime is a third-generation cephalosporin category antibiotic that was developed in 1979 and approved for medical use in 1989 by FDA in the United States. It is a broad-spectrum antibiotic that kills bacteria. It is used for several types of infections like;

• Ear infections
• Sinus infections
• Urinary tract infections
• Gonorrhea
• Typhoid fever
• Pneumonia
• Skin infections

Mechanism of Action of cefixime:

Cefixime breakdown the bacterial cell wall that is responsible for the reproduction of bacteria in the body. This process leads to bacteria dying. It is more resistant to beta-lactamase enzymes than second-generation cephalosporins antibiotics. The chain of bacteria is broken by killing bacteria which produce beta-lactamase enzymes, other antibiotics are inactivated by this enzyme.

The following are some of the most common medical conditions that are treated with Cefixime:

• Acute bacterial sinusitis 
• Acute otitis media
• Uncomplicated gonorrhea
• Acute uncomplicated urinary tract infection
• Acute exacerbation of chronic bronchitis
• Community-acquired pneumonia
• Typhoid fever

The dose of cefixime varies on the symptoms, weight, and age of the patient. The maximum recommended dose of cefixime is 400mg the day. 

Exploring Ofloxacin:

Ofloxacin, a formidable fluoroquinolone antibiotic, wields its potent prowess by meticulously meddling with the intricate web of bacterial DNA. This intricate interference constitutes a formidable barricade against the bacteria's replication, inevitably heralding their demise.

Behold the grandeur of fluoroquinolones, a majestic ensemble of antibiotics that unfurls its omnipotent dominion across a vast spectrum of bacterial adversaries. Notably, Ofloxacin orchestrates its therapeutic symphony primarily against the formidable fortress of gram-negative bacteria, distinguished by their architectural distinctness from their gram-positive counterparts.

Ofloxacin is used to treat a variety of bacterial infections, including:

• Pneumonia
• Cellulitis
• Urinary tract infections
• Prostatitis
• Plague
• Certain types of infectious diarrhea

The synergy of the combination of Cefixime and Ofloxacin

Cefixime and Ofloxacin are two strong antibiotics that work together to treat various bacterial infections. Cefixime works by stopping the growth of bacteria and killing them. Ofloxacin prevents the multiplication and repair of infection-causing bacteria and prevents the further spread of the infection. The multiplication of actions of two medicines makes the bacteria ineffective in a multi-dimensional way.

The combination of Cefixime and Ofloxacin in a single tablet has advantages such as an enhanced spectrum of activity against bacteria and increased effectiveness in complex and resistant infections.

The enhanced spectrum of activity of bacteria: 

The combination of Cefixime and Ofloxacin in a single tablet has an enhanced spectrum of activity against bacteria. Cefixime works by stopping the growth of bacteria by inhibiting the formation of a protective layer required by the bacteria or its growth. Ofloxacin works by preventing the bacteria from reproducing and repairing themselves. Together in a tablet, they treat the infection effectively.

Feature	Cefixime	Ofloxacin
Class	Third-generation cephalosporin	Fluoroquinolone
Mechanism of action	Interferes with bacterial cell wall	Interferes with bacterial DNA
Spectrum of activity	Effective against a wide range of bacteria, including gram-positive and gram-negative bacteria	Effective against a wide range of bacteria, including gram-negative bacteria
Side effects	Common side effects include nausea, vomiting, diarrhea, headache, and dizziness. Serious side effects are rare but can include QT prolongation, tendon rupture, and central nervous system effects.	Common side effects include nausea, vomiting, diarrhea, headache, and dizziness. Serious side effects are rare but can include QT prolongation, tendon rupture, and central nervous system effects.
Dosage	Typically prescribed for 7-10 days	Typically prescribed for 7-10 days

Common Uses of Cefixime and Ofloxacin Tablets

Treating respiratory tract infections with the combination:

The combination of Cefixime and Ofloxacin is very effective in lower respiratory tract infections. The duo antibiotics hit bacteria hard in a synergically way. The effectiveness is fast and significant. 

Managing urinary tract infections effectively:

Simultaneously, Cefixime and Ofloxacin treat urinary tract infections (UTIs) far better than singularly. It is the best combination to treat UTI infections. The success rate of this medicine is higher than second-generation Cephalosporins. 

Combating skin and soft tissue infections:

The combination of cefixime and ofloxacin is often used to treat SSTIs because it is more effective than either antibiotic alone. This is because the two antibiotics work in different ways and target different parts of the bacteria. However, you should not take this medicine without the recommendations of a professional Health practitioner. 

Safety and Precautions:

Common side effects and how to manage them:

CEFIXIME: Side effects of Cefixime drug reactions include diarrhea, dyspepsia, nausea, and vomiting. Hypersensitivity reactions like skin rashes, urticaria, and in some cases, Stevens-Johnson syndrome have been reported.  There is no specific antidote written for Cefixime overdosage. Gastric lavage may be performed. The dialysis process does not remove Cefixime in significant quantities.

Ofloxacin: In general, fluoroquinolones (Ofloxacin) are well tolerated, with most side effects being mild to moderate. On very rare occasions, serious adverse effects occur. Common side effects include gastrointestinal effects such as nausea, vomiting, and diarrhea, as well as headache and insomnia. 

If you see any side effects on you immediately visit your nearest hospital or a doctor. 

Contraindications and drug interactions:

Cefixime and ofloxacin combination tablets are contraindicated in people with the following conditions:

• Known allergy to cefixime, ofloxacin, or other cephalosporins or fluoroquinolones
• Kidney or liver problems
• Epilepsy
• Myasthenia gravis
• QT prolongation
• Pregnancy or breastfeeding

Cefixime and ofloxacin in a tablet may interact with a number of other medications, including:

• Blood thinners
• Anticonvulsants
• Immunosuppressants
• Digoxin
• Theophylline
• Warfarin

CEFIXIME AND OFLOXACIN:CEFFON-OX TABLET

CEFFON-OX TABLET combines three medicaments; Cefixime, Ofloxacin, and Lactic Acid Bacillus.  Cefixime prevents the formation of the new bacterial protective covering which is essential for the survival of the bacteria in the human body. Ofloxacin stops the bacteria from reproducing and repairing themselves in the human body.

Ceffon-OX Tablets are manufactured in GMP-certified companies where all quality parameters are checked while manufacturing the drugs, All analyses are done before releasing it to market.

Ceffon-OX Tablet is packed in elegant Alu Alu packing in a dripoff carton box.

CEFIXIME AND OFLOXACIN TABLET USES: 

CEFFON-OX Cefixime Ofloxacin Tablets work as Cefixime is a cephalosporin antibiotic that treats a wide variety of bacterial infections. Cefixime works by stopping the growth of bacteria in the human body.

This antibiotic treats only bacterial infections like Typhoid in children, It is not given in viral infections (such as the common cold, and flu). Using excessive antibiotics unnecessarily can cause antibiotic resistance to future infections.

CEFIXIME-OFLOXACIN COMBINATION EFFECTIVENESS IN TYPHOID FEVER :

India is reaching fast towards Antimicrobial resistance in the context of typhoid fever. Monotherapy is not found more effective for typhoid fever in India now, then the only practical option is combination therapy. Antibiotic combinations that are approved and available in India for the treatment of typhoid fever are very few, one of them is Cefixime-Ofloxacin. The cefixime-ofloxacin combination is approved by Indian Regulatory Authority In-silico studies have demonstrated a positive rationale for combining these two drugs, while in-vitro studies have substantiated the same by showing a strain-specific synergistic and or additive activity between the two drugs against S. Typhi. Clinical studies in Indian patients have shown huge benefits of using the cefixime-ofloxacin combination in typhoid fever. The first benefit is quick time to defervescence (~3 days), the second is the complete clinical cure of patients in ~7 days only, improving the efficacy in relapse cases. this combination reduced the need for hospitalization for Typhoid fever.

This combination also demonstrates a very good tolerability profile on patients. The Association of Physicians of India Recommends the use of this combination in typhoid fever. So that cefixime-ofloxacin is a safe combination in antimicrobial resistance cases. 

SHORT DESCRIPTION

Brand Name: CEFFON-OX

Dosage Form:  Tablets

Composition:  Cefixime 200mg+Ofloxacin 200mg+Lactic Acid Bacillus 60ms

Packing: 10*10 Alu Alu

MRP: Rs.: 149.00 PER 10 TABLETS.

ALSO AVAILABLE:

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Laricold Tablet: Levocetirizine, Phenylephrine, and Paracetamol tablet.

Rebfon-DSR (Rabeprazole 20mg +Domperidone 30mg)

Down-650 Tablet: Paracetamol tablets IP 650 mg

Mecome-Alpha: Methylcobalamin alpha-lipoic acid pyridoxine Hydrochloride,  folic acid, and Thiamine Mononitrate

DOWN-A SUSPENSION: Aceclofenac and Paracetamol suspension

KUFTIPS SYRUP: An Ayurvedic cough syrup

Itco-200: Itraconazole capsules 200 mg

Laadic-MR Tablet: Diclofenac Potassium, Chlorzoxazone and Paracetamol Tablet.

References:

• A comparative study of ofloxacin and cefixime for treatment of typhoid fever in children. The Dong Nai Pediatric Center Typhoid Study Group [PubLMed] 
• Cefixime Approval by FDA [Accessdata(.fda.gov)]
• Ofloxacin-[Drugbank.online]
• Cefixime-ofloxacin Combination in the Management of Uncomplicated Typhoid Fever in the Indian Community Setting [Journal of The Association of Physicians of India; Vol. 67; March 2019]

Reviewed by;

Dr. Yogesh Chaudhary (B. Pharma)

Senior Pharmacist at S.N. Medical College, Agra-(UP)