Cefixime Oral Suspension Uses
Introduction:
Cefixime oral suspension IP is a cephalosporin-type antibiotic. It is used to treat a wide range of bacterial infections. It can be taken twice a day with or without food. The dosage of Cefixime Oral suspension depends on the basis of the patient's age, weight, and type of infection being treated.
It may have some common side effects such as diarrhea, nausea, vomiting, and abdominal cramps. It may have some rare side effects like Rash, hives, itching swelling of the face and tongue.
Introduction to Ceffon Dry Syrup
Ceffon dry syrup is a combination of two medicaments cefixime 50 mg and Lactic Acid Bacillus 2.5 million spores per 5 ml of reconstituted suspension. The medicine comes in an orange flavor so that kids can swallow it easily, the bitter taste of cefixime is masked very well with different types of taste-masking agents and sugar. It was approved by USFDA in 1986 as the SUPRAX brand name.
Importance of Understanding Cefixime and Lactic Acid Bacillus
Cefixime is a cephalosporin antibiotic that is third generation cephalosorin antibiotic. It is one of most used medicine to treat a wide range of bacterial infections including; Ear infections (acute otitis media), Throat infections (pharyngitis, tonsillitis), Sinus infections (acute sinusitis), Bronchitis, Pneumonia, Urinary tract infections and Skin infections. Lactic acid bacillus is good bacteria that is found in the gut. It is also found in some fermented foods.
When these two ingredients are present in a formulation it makes the medicine more effective and beneficial to stomach health.
Cefixime Oral Suspension IP Uses:
Cefixime dry syrup is used in many bacterial and germicidal infections. The medicine is widely used in cold and cough-like infections along with paracetamol syrup. This is used in Otitis Media infections to get fast and good results.
Cefixime oral suspension is also used in strep throat and urinary tract infections in children. This is the primary drug in such infections and found very efficient over the years.
It is very common to get pneumonia infections in infants and children below 6 years, cefixime oral suspension is used very commonly in Pneumonia. Hence these days due to overuse of antibiotics some children are found to be resistant to cefixime therapy but overall cefixime is used in large numbers.
- It is also used for Lyme disease.
- It acts by inhibiting bacterial cell wall synthesis. The elimination half-life is about 3 hours.
- Bacterias against Used
- Cefixime is used against these bacteria: E. coli, Haemophilus Influenzae, and Proteus Mirabilis.
Side effects of Cefixime Oral Suspension:
Ceffon dry syrup i.e. Cefixime oral suspension is known as the safest antibiotic, but in some rare cases, it may have some adverse effects like Diarrhea, abdominal pain, and nausea. In very few cases allergic reactions may occur which may lead to serious. In some cases, Clostridium problems and chronic bronchitis were also noted.
GI disturbance, Headache, Dizziness, and Rashes.
Cefixime oral suspension IP: Precaution:-
Patients who have a penicillin allergy reaction history should not use cefixime oral suspension without the guidance of a health professional. People with severe renal impairment.
What is cefixime oral suspension used for?
Cefixime oral suspension is used to treat a wide variety of bacterial infections in children. Cefixime is a cephalosporin group antibiotic. It works by stopping the growth of bacteria. Cefixime is used for several other bacterial infections including Stitis media infections, strep throat, Pneumonia, and Typhoid.
Use of Cefixime for Children:
Cefixime is widely used for otitis media, streptococcal pharyngitis, treatment of children with sinusitis, ‘bronchitis’ or pneumonia, urinary tract infection, treatment of uncomplicated gonorrhea infections, gastroenteritis caused by Salmonella and Shigella species.
Drug Interaction:
Cefixime may interact with Salicylic acid and Probenecid.
Cefixime Oral Suspension IP - The Formulation
Composition and Strength (Cefixime 50 mg):
The Cefixime Oral suspension IP contains:
Each 5 ml of reconstituted suspension contains:
Cefixime (As Trihydrate) IP
Eq. to Cefixime 50 mg
Lactic Acid Bacillus 2.5 mg
Dosage Instructions:
In children 8mg/kg body weight daily single dose or two divided doses. Cefixime is not recommended for children below 6 months of age.
Reconstitution Process:
To reconstitute the suspension use in pack Water For Injection, add some WFI to the bottle of Ceffon Dry syrup, shake vigoursly, add more WFI to the bottle and make up the volume up to 30 ml mark on the bottle.
Administration and Storage Guidelines:
It is orally administered medication, that can be taken with a cup of water or juice. Follow the instruction of a doctor or read the instruction given on the label of Ceffon oral suspension outer carton.
Store in a cool, dry and dark place. Do not consume the suspension after 28 days of its reconstitution.
Short Description
BRAND NAME: CEFFON
DOSAGE FORM: ORAL SUSPENSION
COMPOSITION:
Each 5 ml contains
Cefixime IP Eq. to Cefixime 50 mg and Lactic Acid Bacillus 2.5 Million spores
PACKING: 30 ML BOX+28 ML WFI PACK
MRP: Rs. 75.00
ALSO AVAILABLE:
LAAMOX-CV: Amoxycillin and Potassium Clavulanate dry syrup
CEFFON-200: Cefixime and Lactic Acid Bacillus Tablets
POSTPOD-DRY SYRUP: Cefpodoxime 50mg oral suspension.
Ceffon is a substitute product for Zifi dry syrup
There are products that are alternative to Ceffon Dry syrup listed as follow:
Efficacy and Clinical Studies about Cefixime Oral suspension:
Evidence of Efficacy
- According to the data published on the website OptumRx under the heading Clinical Efficacy Summary, "Studies evaluating the third-generation cephalosporins for the treatment of acute exacerbations of chronic bronchitis did not consistently demonstrate significant differences in clinical response or eradication rate when compared to other cephalosporin agents (Alvarez-Sala et al 2006, Fogarty et al 2000, Phillips et al 1993, Van Herwaarden et al 1999, Zuck et al 1999). A study compared cefixime and cephalexin in the treatment of hospitalized patients with exacerbations of chronic bronchitis and demonstrated significantly better clinical cure rates in patients treated with cefixime compared to cephalexin (70.8% vs 50%; p < 0.05)."
- As per the data on the OptumRx "In the treatment of gonorrhea, cefixime, and cefpodoxime have generally demonstrated comparable efficacy in the rate of bacteriologic cure (>90%) in open-label and dose-response studies; cefixime also demonstrated comparable efficacy when compared to ceftriaxone (Handsfield et al 1991, Novak et al 1992, Plourde et al 1992, Portilla et al, 1992, Verdon et al 1993). In a meta-analysis in pregnant women, there was no significant difference between intramuscular ceftriaxone and oral cefixime for gonococcal infection cure based on 1 study and very low-quality evidence"
References:
- Cefixime use in children: When and why-Ben JK Tan, MD
- Cefixime-Wikipedia, the free encyclopedia.
- Cefixime Trihydrate- Antibiotics-Cephalosporins-DRUG TODAY YEARBOOK 2017/PAGE-161
- Food & Drug Administration(.gov):[https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/202091s005,203195s006lbl.pdf]
- Therapeutic Class Overview Cephalosporins, Third-generation-[OptumRx(https://www.medicaid.nv.gov/)]
Disclaimer:
Disclaimer: All the information and articles available on this site are for educational purposes only. The information given here should not be used for the diagnosis or treatment of any health problem or disease without expert advice. The advice of a qualified medical practitioner should always be sought for medical examination and treatment.
Reviewed by;
Dr. Yogesh Chaudhary (B. Pharma)
Senior Pharmacist at S.N. Medical College, Agra-(UP)
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