Lobular-Gm cream is anti-fungal, anti-allergic cream, used in many skin disease. It is available in 15 gm lami tube, with an outer box carton.
Clobetasol propionate IP 0.05% w/w
Neomycin sulphate IP 0.5 % w/w
Miconazole nitrate IP 2.0 % w/w
in a cream base
LOBULAR-GM is indicated in resistant dermatoses where secondary bacterial infection
and/or fungal infection is present, suspected, or likely to occur.
Method of Administration
For topical use only.
Creams are especially appropriate for moist or weeping surfaces.
The following conditions should not be treated with Lobular-GM Cream
• Hypersensitivity to any of the ingredients of the preparation.
• Acne vulgaris.
• Perioral dermatitis.
• Pruritus without inflammation.
• Perianal and genital pruritus.
• Primary cutaneous viral infections (e.g., herpes simplex, chickenpox).
• Primary infected skin lesions caused by infection with fungi, bacteria, or yeast.
• Secondary infections due to Pseudomonas or Proteus species.
• Otitis externa where the eardrum is perforated because of the risk of ototoxicity.
Special Precautions for Use
Pseudomembranous colitis Pseudomembranous colitis has been reported with the use of antibiotics and may range in
severity from mild to life-threatening. Therefore, it is important to consider its diagnosis in
patients who develop diarrhea during or after antibiotic use. Although this is less likely to
occur with topically applied neomycin if prolonged or significant diarrhea occurs or the
patient experiences abdominal cramps, treatment should be discontinued immediately and the
patient investigated further.
Use in Children
In comparison with adults, children may absorb proportionally larger amounts of topical
corticosteroids and thus be more susceptible to systemic adverse effects. This is because
children have an immature skin barrier and a greater surface area to body weight ratio
compared with adults. The use of Lobular-GM in children should be limited to 3 days.
Brand Name: LOBULAR-GM
Dosage Form: Ointment/ External Preparations
Composition: Cobetasol Propionate 0.5%, Neomycin Sulphate 0.5 %, Miconazole Nitrate 2% Cream.
Packing: 15 gm Lami
MRP: Rs. 70.00
Lobular-Plus (Ofloxacin 0.75%, Ornidazole 2%, Itraconazole 1 % and Cobetasol 0.5 % Cream.)
The author has 18 years of experience in the Quality Control, and Quality Assurance departments of Pharmaceutical Manufacturing Companies. Have exposure of all documents for WHO-GMP audits, Export documents, US-FDA documents, Validation of Pharma machinery, and Quality Control Instruments.