Aceclofenac and Paracetamol Tablets | Lace-P Tablet

Darshan Singh

Aceclofenac and Paracetamol Tablets | Lace-P Tablet


Aceclofenac and Paracetamol tablets are a fixed-dose combination of two medications that are used to relieve pain and fever. In this combination, Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) whereas Paracetamol is an antipyretic and analgesic medicine. 

Aceclofenac and Paracetamol tablets are taken by mouth. They usually start working on pain and fever within 30 minutes. This combination has the most common side effects such as nausea, vomiting, and diarrhea. In very rare cases liver damage and kidney damage are possible.  

In combination, Aceclofenac and Paracetamol are more effective than taking them alone for the above-mentioned symptoms.

Lace-P tablet is a combination of Aceclofenac and Paracetamol (100mg: 325mg). It is used for severe and mild fever, body pain, joint pain, arthritis pain, and headache.
Aceclofenac and Paracetamol Tablets

What is Aceclofenac?

Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID). It is used for pain relief and inflammation in several types of arthritis. It works by inhibiting isoforms of the COX enzyme that has a key role in the inflammatory cascade. [1]

Mechanism of Action of Aceclofenac

Aceclofenac is a NSAID. It has many types of mechanisms of action in different symptoms. Primarily, it inhibits the cyclooxygenase (COX) activity that decreases the production of prostaglandins (PGE2) by inflammatory cells by inhibiting IL-Beta and tumor necrosis factors in the inflammatory cells. [2

Second, it inhibits the production of cytokines, interleukins, and necrosis factors (TNF).  

What is Paracetamol?

Paracetamol is also known as Acetaminophen and Para-hydroxy acetanilide. It is the top medicine used to treat fever and mild body pain. It blocks the release of a chemical that is a messenger responsible for pain and fever. Basically, it is an antipyretic and analgesic class medicine.[3

Mechanism of Action of Paracetamol

Paracetamol has different pathways of mechanisms of action that are illustrated below:
  • Inhibition of prostaglandin synthesis: Paracetamol blocks the action of the cyclooxygenase (COX) enzyme which is responsible for the production of prostaglandins[4]
  • Activation of descending serotonergic pathways: Paracetamol is capable to activate the pathways in the human brain that is responsible for pain transmission [5

Lace-P Tablet's Dosage: 

Always follow the instruction of a health professional about the dosage of Lace-P tablet (Aceclofenac 100mg+ Paracetamol 325 mg Tablet). As per CIMS, this tablet can be taken one tablet two times a day. 

Aceclofenac and Paracetamol Tablets Uses

Lace-P tablet is used for mild to high fever, body pain, arthritis pain, joint pain, toothache, headache, etc.

Mechanism of Action of Aceclofenac and Paracetamol Tablets

In the Lace-P tablet, two medicines are presented Aceclofenac (NSAID, painkiller) and Paracetamol (an antipyretic). The presence of two strong antiinflammatory and painkiller molecules makes it a very potent combination against many types of pain due to various reasons.

Aceclofenac and Paracetamol tablets in India

Other Pain Management Products

  • Lace-SP tablet: (Aceclofenac 100mg+ Paracetamol 325 mg+ Serratiopeptidase 15 mg Tablet)
  • Laadic-MR tablet: (Diclofenac Sodium 50mg+ Paracetamol 325mg + Chlorzoxazone 250mg Tablet)
  • Laadic-P tablet: (Diclofenac Potassium 50mg+ Paracetamol 325mg)

Side Effects of Lace-P Tablet

There are not any serious side effect of this combination discovered, usually, side effects of the Lace-P tablet are short and timely and disappears as the body adjusts to the medication. Some common side effects are:
  • Diarrhea
  • Heartburn
  • Nausea
  • Loss of appetite in some cases
  • Pain in stomach
  • Epigastric pain


  • Brand Name: LACE-P
  • Dosage Form: Tablets
  • Composition: Aceclofenac 100 mg.+Paracetamol 325mg
  • Packing: 10×10 Alu alu
  • MRP: 60 PER 10 TABLETS


  • AZIFON-250 (Azithromycin 250mg tablets)
  • CEFFON-200 (Cefixime 200mg +  Lactic acid bacillus 60 million spores)
  • FOLFLOX-OZ: Ornidazole and Ofloxacin Tablet

How to use Pain Medicines safely?

According to the guidelines of the FDA, pain medicines should not use for a long time without the permission or guidance of a healthcare professional. If you are taking medicines for other diseases, ask your doctor before taking any pain or analgesic medicine. Do not use category antihistamines and benzodiazepines when you are using NSAIDs or analgesic medicines. Never drink alcohol in the course of pain medicines. 


  1. Aceclofenac-[Drugbank online]
  2. Aceclofenac Pharmacology [MedicineIndia]
  3. Paracetamol []
  4. Paracetamol – An old drug with new mechanisms of action [Wiley Online Library]
  5. Physiology, Fetal Circulation;by-Kailey Remien; Sapan H. Majmundar.[NIH]
  6. U.S. Food and Drug Department
  7. CIMS magazine
  8. National Library of Medicines


Disclaimer: All the information and articles available on this site are for educational purposes only. The information given here should only be used for the diagnosis or treatment of any health problem or disease with expert advice. The advice of a qualified medical practitioner should always be sought for medical examination and treatment.

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